[Presence of aggregated immunoglobulins on the surface of rapidly dividing antigen-binding lymphocytes]

Rosette-forming cells containing on their surface aggregated immunoglobulins appeared in the fraction of small lymphocytes of the spleen in primary immune response of mice to sheep erythrocytes. These cells effectively incorporate thymidine and can be eliminated in vivo as a result of administration to mice of high doses of tritium labeled base. A conclusion is drawn that the rapidly dividing lymphocytes specifically binding the antigen are characterized by the presence of aggregated immunoglobulins on their surface.