[Interacetion of myeloid and stromal bone marrow elements in acute experimental aplasia]

Acute hypoplasia of the hemopoiesis was induced in guinea pigs by the administration of vynbalstin in a dose of 0.1 mg per 100 g of weight, intraperitoneally, once or twice at an interval of 7 days. Myelokariocyte count, the concentration (per 10(5) of myelokariocytes) and the total amount of the fibroblast precursors was determined in the femur by the fibroblast colony method. After the administration of the cytostatic, simultaneously with the reduction of the myelokariocyte count there was noted a change in the concentration of the stromal precursors and a fall of the total precursor count per femur. It is supposed that the bone marrow reaction under hypoplasia conditions was caused by the interaction of the myeloid and stromal elements.