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Related Experiment Videos

Ramipril-induced decrease in renal lithium excretion in the rat

M Barthelmebs1, M Grima, J L Imbs

  • 1Institut de Pharmacologie (CNRS), Faculté de Médecine, Université Louis Pasteur, Strasbourg, France.

British Journal of Pharmacology
|October 1, 1995
PubMed
Summary
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Ramipril, an angiotensin-converting enzyme inhibitor, reduces lithium excretion in rats. This study compared ramipril

Area of Science:

  • Pharmacology
  • Nephrology
  • Physiology

Background:

  • Lithium is a mood stabilizer with a narrow therapeutic index.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) are known to increase lithium reabsorption.
  • The effect of angiotensin-converting enzyme (ACE) inhibitors on renal lithium handling requires further investigation.

Purpose of the Study:

  • To investigate the interaction of ramipril with renal lithium handling in rats.
  • To compare the effects of ramipril and indomethacin on lithium excretion.
  • To determine if ramipril alters lithium clearance and fractional reabsorption.

Main Methods:

  • Conscious normotensive Wistar rats were treated with ramipril or indomethacin for five days.
  • A single dose of lithium chloride was administered on the fifth day.

Related Experiment Videos

  • Renal function parameters, including lithium clearance and fractional reabsorption, were measured.

    • Main Results:

    • Ramipril decreased renal lithium clearance, correlating with reduced filtered lithium and increased tubular reabsorption.
    • Ramipril also lowered systolic blood pressure by approximately 15 mmHg.
    • Indomethacin increased renal fractional lithium reabsorption without affecting creatinine clearance or blood pressure.

    Conclusions:

    • Ramipril significantly decreases renal lithium excretion in Wistar rats at an oral dose of 1 mg/kg/day over five days.
    • These findings suggest a potential for altered lithium pharmacokinetics when co-administered with ramipril.
    • Further studies are warranted to explore the clinical implications in patients on lithium therapy.