Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Water channels

K Fushimi1, F Marumo

  • 1Second Department of Internal Medicine, School of Medicine, Tokyo Medical and Dental University, Japan.

Current Opinion in Nephrology and Hypertension
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

Aquaporins are water channels in epithelial cells. While their role in water transport is still being studied, new aquaporin members and their functions are being discovered.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hyponatremia with consciousness disturbance caused by omeprazole administration. A case report and literature review.

Digestive diseases and sciences·1996
Same author

Shared amino acid motifs in T-cell receptor beta junctional regions of bronchoalveolar T cells in patients with pulmonary sarcoidosis.

American journal of respiratory and critical care medicine·1996
Same author

Chloride transport across kidney epithelia through CLC chloride channels.

Nihon Jinzo Gakkai shi·1996
Same author

Specific binding sites for proadrenomedullin N-terminal 20 peptide (PAMP) in the rat.

Endocrinology·1996
Same author

Fibrinogen, coagulation factor VII, tissue plasminogen activator, plasminogen activator inhibitor-1, and lipid as cardiovascular risk factors in chronic hemodialysis and continuous ambulatory peritoneal dialysis patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·1996
Same author

Mild hypoxia induces hypertrophy of cultured neonatal rat cardiomyocytes: a possible endogenous endothelin-1-mediated mechanism.

Journal of molecular and cellular cardiology·1996
Same journal

Sex differences in renal acid-base regulation.

Current opinion in nephrology and hypertension·2026
Same journal

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026
Same journal

Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings.

Current opinion in nephrology and hypertension·2026
Same journal

The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter.

Current opinion in nephrology and hypertension·2026
Same journal

Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb.

Current opinion in nephrology and hypertension·2026
Same journal

Social determinants of chronic kidney disease: from association to clinical and population action.

Current opinion in nephrology and hypertension·2026
See all related articles

Area of Science:

  • Physiology
  • Molecular Biology
  • Biochemistry

Background:

  • Aquaporins (water channels) are crucial for fluid transport in epithelia.
  • The precise physiological roles of many aquaporin family members remain unclear.
  • Aquaporin-collecting duct is a known vasopressin-responsive water channel regulated by membrane trafficking.

Purpose of the Study:

  • To investigate the significance of aquaporins in water transport physiology.
  • To explore the regulation and function of different aquaporin water channels.
  • To identify and characterize novel aquaporin members and their physiological roles.

Main Methods:

  • Physiological investigations
  • Genetic studies
  • Analysis of aquaporin localization

Related Experiment Videos

Main Results:

  • Aquaporin channel-like intrinsic protein is found in numerous tissues, but its function is not fully understood.
  • Aquaporin-collecting duct exhibits vasopressin responsiveness and is regulated via a membrane shuttle mechanism.
  • Three distinct models of the water pore have been proposed, requiring further validation.
  • Novel aquaporin members have been identified, with distinct localizations suggesting specific functions.

Conclusions:

  • Aquaporins play diverse roles in water transport across various epithelia.
  • Understanding aquaporin regulation, particularly the membrane shuttle mechanism, is key to comprehending water homeostasis.
  • Further research is needed to elucidate the exact functions and structural models of these vital water channels.