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[Nuclear receptors and ontogenesis of the hematopoietic tissue]
C Chomienne1, F Guidez, J M Micléa
1Laboratoire de Biologie Cellulaire Hématopoïétique, Hôpital Saint-Louis, Paris.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1995
Abstract:
Differentiation of the hematopoietic tissue is controlled by growth factors which act precisely on stem cells arriving at a specific stage of differentiation. The recent identification of retinoic acid, a vitamin A metabolite, as an active differentiating agent of acute promyelocytic leukemia, has allowed to define a normal group of growth and differentiation factors of the myeloid tissue: vitamins A and B and thyroid hormones.