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Related Experiment Videos

[Midazolam versus placebo before spinal anesthesia]

D Fletcher1, K Samii, A Bénichou

  • 1Service d'Anesthésie-Réanimation, Hôpital de Bicêtre, Le Kremlin-Bicêtre.

Cahiers D'Anesthesiologie
|January 1, 1995
PubMed
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Midazolam (M) administered before spinal anesthesia significantly reduced patient anxiety and memory of puncture pain compared to placebo (P). This sedation improved patient comfort during elective surgery procedures.

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Premedication with hydroxyzine is common for elective surgery.
  • Patient comfort during spinal anesthesia procedures is a key concern.

Purpose of the Study:

  • To evaluate the efficacy of midazolam (M) versus placebo (P) for improving patient comfort before spinal anesthesia.
  • To assess the impact of titrated midazolam on anxiety and pain recall.

Main Methods:

  • Randomized, double-blind, multicenter study involving 211 patients.
  • Midazolam (3.4 +/- 1.3 mg) or placebo administered by titration before spinal anesthesia.
  • Patients received oral hydroxyzine premedication.

Main Results:

  • Significantly lower anxiety in the midazolam group (92%) compared to placebo (64%) (p < 0.001).

Related Experiment Videos

  • Reduced recall of puncture pain in the midazolam group (34%) versus placebo (66%) (p < 0.001).
  • No significant difference in patient cooperation or ease of puncture between groups.

    • Conclusions:

    • Titrated midazolam sedation before spinal anesthesia enhances patient comfort.
    • Midazolam effectively reduces pre-procedural anxiety and pain memory.