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Tardive dyskinesia: a review

P R Latimer1

  • 1Department of Psychiatry, Kelowna General Hospital, British Columbia.

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
|September 1, 1995
PubMed
Summary

Tardive dyskinesia (TD) is a disabling movement disorder often linked to antipsychotic medications. Research highlights its iatrogenic nature and the push for safer drug development, though spontaneous forms also exist.

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Area of Science:

  • Neurology
  • Psychiatry

Background:

  • Tardive dyskinesia (TD) is a movement disorder associated with chronic neuroleptic use.
  • Its pathophysiology remains unclear, but it can lead to irreversible cosmetic disfigurement and functional disability.

Purpose of the Study:

  • To review recent research on tardive dyskinesia (TD).
  • To provide findings relevant to clinical practice.

Main Methods:

  • Review of recent research findings on TD.
  • Analysis of TD's association with neuroleptic use, age, and cumulative dosage.

Main Results:

  • Currently, no treatments for TD have demonstrated efficacy.
  • TD incidence increases with age and total cumulative dose of typical neuroleptics.
  • Litigation has driven the development of novel antipsychotic agents.

Conclusions:

  • Spontaneous movement disorders, similar to TD, occur in the elderly and schizophrenia patients.
  • TD is often reversible, contrary to previous understanding.
  • Legal actions have spurred the creation of new antipsychotic medications.

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