Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Perspectives on opioid tolerance from basic research: behavioural studies after spinal administration in rodents

C W Stevens1

  • 1Department of Pharmacology, Oklahoma State University, College of Osteopathic Medicine, Tulsa 74107-1898, USA.

Cancer Surveys
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case of Cholera-Infantum with Anuria for Five Days: Recovery.

The Georgia medical companion·2022
Same author

Evaluating Effects of Radiation Therapy Treatment on 4DCT-Calculated Lung Ventilation.

Practical radiation oncology·2014
Same author

Effects of Noise in 4D CT on Deformable Image Registration and Derived Ventilation Data.

Practical radiation oncology·2014
Same author

Deformable Imaging Capability for the Radiation Therapy Oncology Group (RTOG) Consensus Atlas of Musculoskeletal Anatomy (CAMAS) for Soft Tissue Sarcoma of the Lower Extremities.

Practical radiation oncology·2014
Same author

Pharmacological characterization of LPS and opioid interactions at the toll-like receptor 4.

British journal of pharmacology·2012
Same author

Acquiring 4D thoracic CT scans using a multislice helical method.

Physics in medicine and biology·2004

Opioid tolerance develops at a consistent rate across different drugs and doses. More potent opioids may lead to less tolerance, suggesting clinical use of agents like fentanyl over morphine for long-term pain management.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Pain Management

Background:

  • Opioid tolerance is a significant clinical challenge in managing chronic pain.
  • Existing literature lacks systematic investigation into the rate of opioid tolerance development.
  • Understanding tolerance mechanisms is crucial for rational opioid selection and treatment strategies.

Purpose of the Study:

  • To systematically investigate the rate of opioid tolerance development across various opioid agents.
  • To test the hypothesis that more potent agonists produce less tolerance.
  • To elucidate the mechanisms of opioid cross-tolerance and inform clinical practice.

Main Methods:

  • Computer modeling and statistical analysis of analgesic effect decay using an exponential function.

Related Experiment Videos

  • Time-course analysis of tolerance development in animal models.
  • Literature review on opioid tolerance and cross-tolerance.

    • Main Results:

    • Opioid tolerance appears to develop at a uniform rate irrespective of drug or dose.
    • Preliminary evidence supports the hypothesis that more potent opioids induce less tolerance.
    • Cross-tolerance is predicted among agents acting on the same receptors, and on different receptors if pharmacological synergy exists.

    Conclusions:

    • Opioid tolerance may develop at a predictable rate, informing rational clinical choices.
    • Potent opioids like fentanyl could be viable alternatives to morphine for long-term pain management.
    • Quantitative assessment of tolerance and cross-tolerance is essential for effective patient treatment plans.