Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tolerance to opioid analgesics: clinical aspects

R K Portenoy1

  • 1Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Cancer Surveys
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improvements in Survival and Clinical Benefit With Gemcitabine as First-Line Therapy for Patients With Advanced Pancreas Cancer: A Randomized Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2023
Same author

Pharmacotherapy of Cancer PainA Practical Guide.

Journal of back and musculoskeletal rehabilitation·2014
Same author

Evaluation of back pain caused by epidural neoplasm.

Journal of back and musculoskeletal rehabilitation·2014
Same author

Physician board certification in hospice and palliative medicine.

Journal of palliative medicine·2005
Same author

Does an oral analgesic protocol improve pain control for patients with cancer? An intergroup study coordinated by the Eastern Cooperative Oncology Group.

Annals of oncology : official journal of the European Society for Medical Oncology·2005
Same author

Ethical challenges in the care of patients with serious illness.

Pain medicine (Malden, Mass.)·2004

True pharmacological tolerance to opioid analgesics is uncommon in clinical pain management. Pain mechanisms, not just drug exposure, significantly influence tolerance development and opioid dose escalation.

Area of Science:

  • Pharmacology
  • Pain Management
  • Clinical Therapeutics

Background:

  • Opioid tolerance is a complex phenomenon impacting therapeutic efficacy.
  • Clinical understanding is limited by communication gaps between clinicians and researchers.
  • Existing research often relies on animal models or studies of former addicts.

Purpose of the Study:

  • To clarify the clinical relevance of opioid tolerance in pain management.
  • To differentiate true pharmacological tolerance from other causes of dose escalation.
  • To explore the influence of pain itself on tolerance development.

Main Methods:

  • Review of clinical observations regarding opioid dose-response in pain patients.
  • Analysis of experimental literature on opioid tolerance in animal models and former addicts.

Related Experiment Videos

  • Comparison of clinical findings with experimental data.

    • Main Results:

    • True pharmacological tolerance to opioid analgesics is rarely the sole cause for dose escalation in clinical pain.
    • Tolerance to non-analgesic opioid effects occurs more frequently but is variable.
    • Pain modulation appears to significantly influence tolerance phenomena.

    Conclusions:

    • Clinical observations on opioid tolerance differ from experimental findings.
    • Pain itself plays a crucial role in modulating opioid tolerance.
    • Caution is needed when extrapolating animal or former addict data to clinical pain settings.