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Dapsone-induced motor peripheral neuropathy in pemphigus foliaceus
L E Rhodes1, M D Coleman, M S Lewis-Jones
1Department of Dermatology, Royal Liverpool University Hospital, UK.
Clinical and Experimental Dermatology
|March 1, 1995
Summary
Pemphigus foliaceus can rarely cause dapsone-induced motor peripheral neuropathy. This rare side effect developed quickly and was severe and long-lasting in this patient.
Area of Science:
- Dermatology
- Neurology
Background:
- Pemphigus foliaceus is a chronic autoimmune blistering skin disease.
- Dapsone is a medication used to treat various conditions, including leprosy and certain dermatoses.
Observation:
- A patient with pemphigus foliaceus developed motor peripheral neuropathy.
- The neuropathy emerged rapidly within one month of starting dapsone treatment.
Findings:
- This case highlights an idiosyncratic and rare adverse effect of dapsone therapy.
- The neuropathy was characterized by its rapid onset, profound severity, and prolonged duration.
Implications:
- Clinicians should be vigilant for peripheral neuropathy as a potential complication of dapsone treatment, even in non-leprosy patients.
- Early recognition and management are crucial for mitigating the impact of this severe side effect.