Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epigenetic programming of differential gene expression in development and evolution

M Monk1

  • 1Molecular Embryology Unit, Institute of Child Health, London, United Kingdom.

Developmental Genetics
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026
Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026
Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026
Same author

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Physical review letters·2026
Same author

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

Physical review letters·2026
Same author

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Physical review letters·2026
Same journal

A Message From the Editor.

Developmental genetics·1999
Same journal

Telomerase activity and telomere detection during early bovine development.

Developmental genetics·1999
Same journal

Maternal function of a retroviral-type zinc-finger protein is essential for Drosophila development.

Developmental genetics·1999
Same journal

Misexpression of argos, an inhibitor of EGFR signaling in oogenesis, leads to the production of bicephalic, ventralized, and lateralized Drosophila melanogaster eggs.

Developmental genetics·1999
Same journal

Spatial pattern of constitutive and heat shock-induced expression of the small heat shock protein gene family, Hsp30, in Xenopus laevis tailbud embryos.

Developmental genetics·1999
Same journal

Distinct functions for Aldh1 and Raldh2 in the control of ligand production for embryonic retinoid signaling pathways.

Developmental genetics·1999
See all related articles

DNA methylation patterns regulate gene expression during mouse embryonic development. This review explores epigenetic inheritance and its role in evolution, challenging traditional genetic models.

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Evolutionary Biology

Background:

  • DNA methylation patterns are crucial for regulating gene expression during mammalian embryonic development.
  • Dynamic changes in DNA methylation, including demethylation and de novo methylation, occur during preimplantation and postimplantation stages.
  • X-chromosome inactivation in female embryos serves as a model to study methylation's role in gene activity regulation.

Purpose of the Study:

  • To review data on changing DNA methylation patterns and gene expression regulation in mouse embryonic development.
  • To elucidate the role of DNA methylation in the initiation and maintenance of differential gene activity using X-chromosome inactivation as a model.
  • To present a hypothesis of adaptive epigenetic/genetic inheritance and its implications for evolution.

Related Experiment Videos

Main Methods:

  • Analysis of DNA methylation patterns at specific CpG sites in X-linked genes (Pgk-1, G6pd, Xist) during mouse embryonic development.
  • Utilizing X-chromosome inactivation in female embryos as a model system.
  • Reviewing existing data and proposing theoretical models for epigenetic inheritance and evolution.

Main Results:

  • Global demethylation occurs from the eight-cell to blastocyst stage, with de novo methylation beginning at implantation.
  • Methylation of X-linked housekeeping genes closely precedes their inactivation, suggesting a role in initiation and maintenance.
  • A methylation difference in the Xist gene promoter correlates with imprinted paternal X chromosome inactivation in extra-embryonic tissues.

Conclusions:

  • DNA methylation plays a critical role in regulating gene expression during embryonic development and X-chromosome inactivation.
  • Epigenetic inheritance, involving modifications in germ line DNA in response to environmental changes, is proposed as a mechanism for adaptation.
  • Adaptive epigenetic/genetic inheritance challenges the central dogma and Darwinian evolution, suggesting alternative pathways for evolutionary change.