Alteration of sialoglycoprotein in the glomerular basement membrane of diabetic glomerulosclerosis

The alteration of glycoprotein in the glomerular basement membrane in diabetic glomerulosclerosis was studied with preparative polyacrylamide gel electrophoresis by Uniphor column. Normal glomerular basement membrane was fractionated into 32 glycoprotein fractions. Decrease in sialic acid residue of sialoprotein was the characteristic finding observed in diabetic glomerulosclerosis. A hypothesis which explains the alteration of sialoglycoprotein is proposed.