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Related Experiment Videos

Spirometric versus Fick-derived oxygen consumption: which method is better?

D N Thrush1

  • 1Department of Anesthesiology, University of South Florida College of Medicine, Tampa, USA.

Critical Care Medicine
|January 1, 1996
PubMed
Summary

The Fick equation for measuring oxygen consumption (VO2) showed significant bias compared to spirometry in pigs. These findings suggest caution when using Fick-derived VO2 for critical care decisions.

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Area of Science:

  • Physiology
  • Critical Care Medicine

Background:

  • Oxygen consumption (VO2) is crucial for assessing critically ill patients.
  • The Fick equation is a common method for calculating VO2, relying on cardiac output and arterial-venous oxygen content difference.

Purpose of the Study:

  • To compare the accuracy of VO2 measurements using the Fick equation against a spirometric technique.
  • To evaluate the interchangeability of these two methods for VO2 determination.

Main Methods:

  • A prospective study was conducted in a university laboratory setting using nineteen adult pigs.
  • VO2 was calculated via the Fick equation using cardiac output (thermodilution) and oxygen content (galvanic fuel cell).
  • A spirometric technique measured VO2 by oxygen disappearance rate; VO2 was pharmacologically varied (dobutamine, labetalol).

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Main Results:

  • A bias of 58 mL/min and a precision (SD of bias) of 35 mL/min were observed between Fick-derived and spirometrically measured VO2.
  • Fick-derived VO2 values were consistently higher than those measured spirometrically.
  • A strong correlation (r=0.90) was found, but a significant unexplained difference persisted.

Conclusions:

  • Despite efforts to minimize error, a notable discrepancy exists between Fick and spirometric VO2 measurements.
  • The Fick method and spirometry are not interchangeable for VO2 determination.
  • Caution is advised when utilizing Fick-derived VO2 data for therapeutic decisions in critical care.