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Increased resting lipid oxidation in Crohn's disease
G Mingrone1, A V Greco, G Benedetti
1Cattedra di Medicina Interna, Policlinico A. Gemelli, Universita Cattolica del Sacro Cuoro, Rome, Italy.
Digestive Diseases and Sciences
|January 1, 1996
Summary
Crohn
Area of Science:
- Gastroenterology
- Nutritional Science
- Metabolic Research
Background:
- Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract.
- Patients with CD often experience altered body composition and metabolic changes.
- Understanding energy expenditure and substrate utilization is crucial for managing CD.
Purpose of the Study:
- To investigate resting energy expenditure (REE) and body composition in patients with ileal Crohn's disease.
- To compare metabolic parameters between Crohn's disease patients and healthy controls.
- To explore the implications of altered metabolism for nutritional management in Crohn's disease.
Main Methods:
- Indirect calorimetry was used to measure resting energy expenditure (REE).
- Body composition was assessed using bioimpedance and anthropometry.
- Study included 20 hospitalized Crohn's disease patients and 16 healthy controls.
Main Results:
- Crohn's disease patients had significantly lower body weight, fat mass, and lean body mass compared to controls.
- While average REE was higher in controls, REE normalized to lean body mass (LBM) showed no significant difference.
- Patients exhibited a lower nonprotein respiratory quotient, indicating increased lipid oxidation.
Conclusions:
- Increased lipid oxidation in Crohn's disease patients may contribute to reduced fat stores.
- Normalized REE suggests metabolic derangements are linked to lean body mass.
- A lipid-rich diet may be beneficial for the nutritional management of Crohn's disease patients.