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The effects of hormone replacement therapy on uterine fibroids in postmenopausal women
A B Sener1, N C Seçkin, S Ozmen
1Dr. Zekai Tahir Burak Women's Hospital, Menopause Center, Ankara, Turkey.
Objective:
To evaluate and compare the effects of two different modalities of hormone replacement therapy (HRT) on the size of uterine fibroids.
Design:
Randomized clinical study.
Setting:
The Menopause Center of a public hospital.
Patients:
Postmenopausal women with small asymptomatic uterine fibroids were selected.
Interventions:
One group was treated with 50 micrograms transdermal E2 plus 5 mg medroxyprogesterone acetate (MPA) continuously, whereas the second group was given 0.625 mg conjugated equine estrogen plus 2.5 mg MPA continuously.
Main Outcome Measure:
The size of the uterine fibroids was measured before and after the first year of HRT.
Results:
At the end of the first year on HRT, the size of the uterine fibroids was re-evaluated sonographically and no significant difference was found with the oral group, whereas there was a significant increase in the transdermal group.
Conclusion:
Hormone replacement therapy with 50 micrograms transdermal E2 plus 5 mg MPA increases the size of the uterine fibroids.