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A fatal dothiepin overdose

V Cirimele1, P Kintz, A Tracqui

  • 1Institut de Médecine Légale, Strasbourg, France.

Forensic Science International
|December 29, 1995
PubMed
Summary
This summary is machine-generated.

This study quantifies dothiepin in biological samples following an overdose. Dothiepin was detected in blood and hair, indicating chronic antidepressant use.

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Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry

Background:

  • Assessing drug concentrations in biological matrices is crucial for forensic investigations.
  • Dothiepin (Prothiaden) is a tricyclic antidepressant with potential toxicity.

Observation:

  • Analysis of biological fluids, tissues, and hair was performed using high-pressure liquid chromatography and gas chromatography-mass spectrometry.
  • Quantification of dothiepin was conducted in a fatal overdose case.

Findings:

  • Blood dothiepin concentration was measured at 5.75 mg/l.
  • Hair analysis revealed a dothiepin concentration of 1.89 ng/mg, suggesting chronic antidepressant exposure.

Implications:

  • These findings provide valuable toxicological data for cases involving dothiepin ingestion.
  • The study highlights the utility of hair analysis in detecting long-term drug use.