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Related Experiment Videos

Nitroprusside suppresses cochlear potentials and outer hair cell responses

C Chen1, A Nenov, R Skellett

  • 1Kresge Hearing Research Laboratory of the South, Department of Otorhinolaryngology and Biocommunication, Louisiana State University Medical Center, New Orleans 70112-2234, USA.

Hearing Research
|July 1, 1995
PubMed
Summary

Sodium nitroprusside (SNP), a nitric oxide (NO) donor, impaired cochlear function in vivo and in vitro. SNP reduced sound-evoked responses and outer hair cell activity, suggesting NO

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Area of Science:

  • Oto-neuroscience
  • Auditory physiology
  • Pharmacology

Background:

  • Nitric oxide (NO) is implicated in cochlear function.
  • Investigating NO's role requires specific pharmacological tools.

Purpose of the Study:

  • To evaluate the effects of sodium nitroprusside (SNP), an NO donor, on cochlear function.
  • To determine SNP's impact on sound-evoked potentials and outer hair cell (OHC) activity.

Main Methods:

  • In vivo intracochlear perfusion of SNP in guinea pigs.
  • In vitro assessment of OHC voltage-induced length changes and currents.
  • Measurement of cochlear microphonic (CM), summating potential (SP), endocochlear potential (EP), and compound action potential (CAP).

Main Results:

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  • SNP dose-dependently reduced all sound-evoked cochlear responses in vivo.
  • SNP significantly decreased OHC voltage-induced length changes and outward currents in vitro.
  • High concentrations of SNP rapidly reduced the endocochlear potential (EP).

Conclusions:

  • SNP, likely via released NO, affects cochlear function.
  • Potential sites of action include the stria vascularis and outer hair cells.
  • NO may play a modulatory role in auditory signal processing.