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Oxidants and antioxidants in exercise

C K Sen1

  • 1Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|September 1, 1995
PubMed
Summary

Strenuous exercise can overwhelm antioxidant defenses, leading to oxidative stress. Combining regular physical activity with a diet rich in antioxidants may offer protective benefits against exercise-induced damage.

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Area of Science:

  • Exercise physiology
  • Biochemistry
  • Nutritional science

Background:

  • Strenuous physical exercise generates excess reactive oxygen species (ROS), potentially overwhelming the body's antioxidant defenses.
  • Both physiological and dietary antioxidants play crucial roles in mitigating exercise-induced oxidative stress.
  • While exercise training can enhance antioxidant capacity, it may not fully protect highly fit individuals during exhaustive exertion.

Purpose of the Study:

  • To review the current understanding of exercise-induced oxidative stress.
  • To explore the role of antioxidant defenses in mitigating this stress.
  • To discuss the potential benefits of combining physical activity with antioxidant supplementation.

Main Methods:

  • Review of existing human and animal studies on exercise and oxidative stress.
  • Analysis of the interplay between physiological and dietary antioxidants.
  • Examination of the effects of different exercise intensities and durations on antioxidant status.

Main Results:

  • Consistent evidence indicates strenuous exercise induces oxidative stress by overwhelming antioxidant defenses.
  • Submaximal, long-duration exercise training can augment tissue antioxidant defenses.
  • Enhanced antioxidant defenses may not be sufficient to fully protect highly fit individuals from exhaustive exercise-induced oxidative stress.

Conclusions:

  • Regular physical activity combined with adequate dietary antioxidant intake is recommended for optimal protection.
  • Further research is needed to fully elucidate the complex interactions between exercise, antioxidants, and oxidative stress.
  • This area of research holds significant implications for sports performance and health maintenance.

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