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Related Experiment Videos

CD30 expression does not discriminate between human Th1- and Th2-type T cells

D Hamann1, C M Hilkens, J L Grogan

  • 1Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, The Netherlands.

Journal of Immunology (Baltimore, Md. : 1950)
|February 15, 1996
PubMed
Summary

CD30 expression can be induced on activated T cells regardless of their Th0, Th1, or Th2 differentiation. This finding challenges the notion that CD30 is exclusively a marker for Th2-type T cells.

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Area of Science:

  • Immunology
  • Cell Biology
  • T cell differentiation

Background:

  • CD30, a TNF receptor superfamily member, is a marker for Hodgkin's disease.
  • Recent studies suggest CD30 is preferentially upregulated on Th2-type human T cells.

Purpose of the Study:

  • To investigate the regulation of CD30 expression on human T cells.
  • To determine if CD30 expression is linked to specific T helper cell differentiation pathways (Th0, Th1, Th2).

Main Methods:

  • Analysis of CD30 expression on peripheral blood T cells and T cell clones.
  • Short-term T cell cultures stimulated with various antigens (Schistosoma haematobium, Toxocaria canis, tetanus toxoid, tuberculin purified protein derivative).
  • Simultaneous measurement of membrane phenotype and cytokine production (including IFN-gamma).

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Main Results:

  • CD30 expression was induced on T cells by antigens eliciting Th2, Th0, and Th1 responses.
  • CD30-expressing T cells were found to produce IFN-gamma.
  • CD30 was expressed on Th0, Th2, and Th1 type T cell clones.

Conclusions:

  • Induction of CD30 on activated T cells is not associated with their differentiation into Th0, Th1, or Th2 subtypes.
  • CD30 expression on activated T cells is a general phenomenon, not specific to Th2-type cells.