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Related Experiment Videos

IGF-II and IGF-binding proteins increase dramatically during rabbit pregnancy

K S Nason1, N D Binder, J I Labarta

  • 1Department of Pediatrics, Oregon Health Sciences University, Portland 97201, USA.

The Journal of Endocrinology
|January 1, 1996
PubMed
Summary

Pregnancy alters the insulin-like growth factor (IGF) axis in rabbits, impacting maternal metabolism and weight. Dramatic changes in IGF-I, IGF-II, and IGF-binding proteins occur, coinciding with conceptus growth and placental development.

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Area of Science:

  • Reproductive biology
  • Endocrinology
  • Maternal-fetal physiology

Background:

  • The insulin-like growth factor (IGF) axis plays a crucial role in regulating maternal metabolism and nutrient distribution during pregnancy.
  • Understanding these changes is vital for supporting successful gestation and conceptus development.

Purpose of the Study:

  • To investigate the dynamic changes in the maternal IGF axis, including IGF-I, IGF-II, and IGF-binding proteins (IGFBPs).
  • To correlate these hormonal shifts with maternal weight fluctuations and food intake throughout pregnancy in New Zealand White rabbits.

Main Methods:

  • Serial measurements of maternal serum IGF-I, IGF-II, and IGFBPs were performed in pregnant rabbits from pre-breeding to term.
  • Maternal body weight and food consumption were monitored throughout the study period.

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  • Western-ligand blotting was used to assess IGFBP profiles.

    • Main Results:

    • Maternal body weight increased, but maternal tissue mass initially rose then declined, with final weight gain attributed to conceptus growth.
    • Serum IGF-I levels peaked mid-pregnancy, while IGF-II and IGFBP levels, particularly IGFBP-3, showed dramatic increases during the second half of gestation before declining.
    • Food intake decreased significantly only in the final days of pregnancy.

    Conclusions:

    • The maternal IGF axis undergoes significant and unique alterations during rabbit pregnancy, closely linked to maternal physiological adaptations and conceptus development.
    • These hormonal changes, especially the surge in IGF-II and IGFBPs, may play a critical role in nutrient management and supporting fetal growth.
    • The observed timing of IGF axis changes suggests a potential link to the transition from yolk sac to placental function in rabbits.