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Hemangiomas and hemangiosarcomas in inbred laboratory mice
1BASF Bioresearch Corporation, Worcester, Massachusetts, USA.
Laboratory Animal Science
|October 1, 1995
Summary
This study investigated spontaneous blood vessel tumors (hemangiomas and hemangiosarcomas) in mice. No sexual dimorphism was observed in tumor development across multiple inbred strains.
Area of Science:
- Veterinary Pathology
- Oncology
- Mouse Models
Background:
- Hemangiomas and hemangiosarcomas are rare vascular tumors.
- Spontaneous tumor development in inbred mouse strains provides models for human disease.
Purpose of the Study:
- To characterize spontaneous hemangiomas and hemangiosarcomas in specific inbred mouse strains.
- To determine if sexual dimorphism influences the incidence of these vascular tumors.
Main Methods:
- Retrospective analysis of tumor incidence in six inbred mouse strains over 57 months.
- Immunohistochemical analysis using von Willebrand factor and smooth muscle actin antibodies.
- Correlation of tumor data with mouse sex and age.
Main Results:
- Fifteen cases of spontaneous vascular tumors (11 hemangiomas, 3 hemangiosarcomas) were identified.
- Tumors occurred across multiple strains and affected various tissues, primarily skin.
- No statistically significant sexual dimorphism in tumor occurrence was detected.
- Immunohistochemistry showed inconsistent labeling of endothelial cells but outlined vascular structures.
Conclusions:
- Spontaneous hemangiomas and hemangiosarcomas occur in these mouse strains without sexual predilection.
- These findings contribute to understanding spontaneous vascular tumor development in mice.
- Further research may refine immunohistochemical markers for mouse vascular tumors.
