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Related Experiment Videos

Annexin II tetramer: structure and function

D M Waisman1

  • 1Department of Medical Biochemistry, Faculty of Medicine, University of Calgary, Alberta, Canada.

Molecular and Cellular Biochemistry
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

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Annexin II tetramer, a protein involved in membrane trafficking, bridges secretory granules to plasma membranes, suggesting a role in calcium-dependent exocytosis. It also mediates cell-cell adhesion in metastatic cells.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Annexins are Ca2+-dependent acidic phospholipid-binding proteins.
  • Their membrane interactions suggest roles in membrane trafficking (exocytosis, endocytosis, cell adhesion).
  • Annexin II exists as monomer, heterodimer, or heterotetramer.

Purpose of the Study:

  • Investigate the role of annexin II tetramer in Ca2+-dependent exocytosis.
  • Explore annexin II tetramer's function in cell-cell adhesion, particularly in metastasis.
  • Examine the regulatory mechanisms of annexin II tetramer function.

Main Methods:

  • The abstract does not specify methods.

Main Results:

  • Annexin II tetramer bridges secretory granules to plasma membranes, indicating a role in Ca2+-dependent exocytosis.

Related Experiment Videos

  • Annexin II tetramer is found on the extracellular face of metastatic cells, mediating cell-cell binding.
  • Annexin II tetramer is a substrate for protein kinase C and pp60src.
  • Phosphorylation negatively modulates annexin II tetramer function.

    • Conclusions:

    • Annexin II tetramer plays a significant role in Ca2+-dependent exocytosis.
    • Annexin II tetramer contributes to cell-cell adhesion in metastatic processes.
    • Protein kinase C and pp60src phosphorylation regulate annexin II tetramer activity.