Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipoprotein receptor 'CK'--dependent signalling in human platelets

D Kaul1, N Kochhar, J Singh

  • 1Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Molecular and Cellular Biochemistry
|October 18, 1995
PubMed
Summary

Low-density lipoprotein (LDL) initiates a signaling pathway in platelets, similar to cholesterol. High-density lipoprotein (HDL) and other compounds inhibit this LDL-induced platelet activation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of patients with epithelioid hemangioendothelioma (EHE): a retrospective analysis of the Charité- Universitätsmedizin Berlin.

Journal of cancer research and clinical oncology·2026
Same author

A phase 2 multicenter, prospective, randomized, double-blind study to assess the clinical and antiviral efficacy and safety of nitazoxanide for the treatment of norovirus in hematopoietic stem cell and solid organ transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Thrombus or tumor? A case report of a rare sarcoma entity: intimal sarcoma of the pulmonary arteries.

Molecular biology reports·2024
Same author

Impact of meltwater flow intensity on the spatiotemporal heterogeneity of microbial mats in the McMurdo Dry Valleys, Antarctica.

ISME communications·2023
Same author

Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations : An overview and recommendations of the consortium academic radiation oncology of the German Society for Radiation Oncology (DEGRO).

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2021
Same author

Correction to: Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer-results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2021

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Platelet signaling is crucial for hemostasis and thrombosis.
  • Lipoproteins, including LDL and HDL, play roles in cardiovascular health.
  • Receptor-'C' is implicated in cellular signaling pathways.

Purpose of the Study:

  • To investigate if low concentrations of lipoproteins modulate Receptor-'C' dependent platelet signaling.
  • To elucidate the role of LDL and cholesterol in initiating platelet signaling.
  • To define the lipoprotein-dependent platelet signaling pathway.

Main Methods:

  • Investigated the effect of LDL and cholesterol on platelet signaling.
  • Assessed the influence of HDL, cAMP, cGMP, DTT, Zn++, and butanol on LDL-induced signaling.

Related Experiment Videos

  • Examined Receptor-'C' autophosphorylation and its tyrosine kinase activity in purified platelets.

    • Main Results:

    • LDL initiated Phospholipase D (PLD)-dependent platelet signaling in a dose-dependent manner.
    • HDL, cAMP, DTT, Zn++, and butanol inhibited LDL-induced PLD activity, while cGMP had no effect.
    • Purified Receptor-'C' exhibited LDL- and cholesterol-dependent autophosphorylation, indicating Receptor-'C' tyrosine kinase (Receptor-Ck) activity.

    Conclusions:

    • Receptor-'C' tyrosine kinase activity is a key mediator of LDL- and cholesterol-dependent PLD activity in human platelets.
    • A lipoprotein-dependent platelet signaling pathway involving Receptor-'C' has been proposed.
    • These findings contribute to understanding lipoprotein's role in platelet function.