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Fungaemia in hospitalized patients
M Perduca1, E Marangoni, A Guanziroli
1Institute of Microbiology, University of Pavia, Italy.
Mycoses
|September 1, 1995
Summary
A 4-year study of immunocompromised patients found 36% of blood cultures were positive for fungal infections. Candida species were most common, followed by Cryptococcus neoformans, highlighting the need for mycological surveillance.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Immunocompromised patients are at high risk for invasive fungal infections.
- Bloodstream infections pose significant morbidity and mortality in this population.
- Early detection of fungal pathogens is crucial for effective treatment.
Purpose of the Study:
- To investigate the mycological profile of bloodstream infections in immunocompromised patients.
- To identify the prevalence and species distribution of fungi in blood cultures.
- To assess the etiological agents of fungemia in a tertiary care hospital.
Main Methods:
- Retrospective analysis of 269 blood cultures from immunocompromised patients over four years.
- Mycological examination of blood cultures.
- Identification of fungal species using standard laboratory techniques.
Main Results:
- 36% of blood cultures were positive for fungal growth (96 out of 269).
- Candida species were the most frequently isolated fungi (48% C. albicans, 8% C. tropicalis, 8% C. parapsilosis, 3% C. glabrata, 3% C. guillermondii).
- Cryptococcus neoformans was identified in 22% of positive cultures (21 patients).
Conclusions:
- Fungal bloodstream infections are a significant concern in immunocompromised patients.
- Candida species, particularly C. albicans, are the leading cause of fungemia.
- Cryptococcus neoformans is also a notable pathogen in this patient group, warranting specific diagnostic attention.