Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Flavonoid constituents from Eupatorium altissimum L. (Compositae)

R H Dobberstein, M Tin-wa, H H Fong

    Journal of Pharmaceutical Sciences
    |April 1, 1977
    PubMed
    Summary

    Eupatorium altissimum L. extract demonstrated antitumor and cytotoxic effects in preclinical models. However, isolated flavones eupatorin and 5-hydroxy-3

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of heavy water on the germination of a number of species of seeds.

    Planta·2014
    Same author

    Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal.

    Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
    Same author

    Cell culture assay system for the evaluation of natural product-mediated anti-Hepatitis B virus activity.

    Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
    Same author

    Editorial.

    Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
    Same author

    Isolation of gallic acid esters as antiplasmodial constituents of Swintonia foxworthyi (Anacardiaceae).

    Phytomedicine : international journal of phytotherapy and phytopharmacology·2012
    Same author

    Effects of Ayahuasca on the human EEG.

    Phytomedicine : international journal of phytotherapy and phytopharmacology·2012

    Area of Science:

    • Phytochemistry
    • Pharmacology
    • Cancer Research

    Background:

    • Eupatorium altissimum L. (Compositae) is a plant with potential medicinal properties.
    • Natural products are a rich source of novel therapeutic agents.

    Purpose of the Study:

    • To investigate the cytotoxic and antitumor activities of Eupatorium altissimum L. extracts.
    • To isolate and identify active compounds responsible for the observed bioactivity.

    Main Methods:

    • Aqueous ethanol extraction of Eupatorium altissimum L.
    • Bioassays including P-388 lymphocytic leukemia assay in mice and 9KB cell culture assay.
    • Chromatographic isolation and structural elucidation of compounds.

    Main Results:

    Related Experiment Videos

  • The aqueous ethanol extract exhibited antitumor activity in the P-388 assay.
  • Chloroform soluble fractions showed both cytotoxic and antitumor activities.
  • Two flavones, eupatorin and 5-hydroxy-3',4',6,7-tetramethoxyflavone, were isolated.

    • Conclusions:

    • Eupatorium altissimum L. extract possesses significant antitumor and cytotoxic properties.
    • The isolated flavones, eupatorin and 5-hydroxy-3',4',6,7-tetramethoxyflavone, did not exhibit cytotoxic or antitumor activity in this study.
    • Further research is needed to identify the specific compounds responsible for the extract's activity.