Simultaneous GLC determination of acetaminophen, dichloralantipyrine, and isometheptene mucate

A rapid GLC assay for acetaminophen, dichloralantipyrine, and isometheptene mucate in capsules was developed. These substances are chromatographed directly, using phenyl methyl silicone gum as the stationary phase. The standard calibration curves are linear up to 14 mg/ml, with a lower limit of sensitivity of 2 mg/ml. This method is simple and rapid and does not require derivative formation.