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[Acute pancreatitis caused by metronidazole]
F E de Jongh1, J P Ottervanger, P C Stuiver
1Havenziekenhuis, afd. Inwendige Geneeskunde en Tropische Ziekten, Rotterdam.
Abstract:
A 45-year-old woman in the period 1988-1995 suffered three episodes of acute pancreatitis associated with the use of metronidazole. On each occasion the pancreatitis subsided after withdrawal of metronidazole. Pancreatitis is a very infrequent, but potentially dangerous adverse effect of metronidazole. The exact pathogenetic mechanism of metronidazole-induced pancreatitis remains to be determined.
Insights
Metronidazole can cause acute pancreatitis, a rare but serious side effect. Symptoms resolved after discontinuing the medication, highlighting a potential link between metronidazole use and pancreatitis.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Metronidazole is a widely used antibiotic.
- Adverse drug reactions require careful monitoring.
Observation:
- A patient experienced recurrent acute pancreatitis between 1988 and 1995.
- Each pancreatitis episode coincided with metronidazole use.
Findings:
- Pancreatitis symptoms resolved upon metronidazole withdrawal.
- This suggests metronidazole as a potential cause of pancreatitis in this case.
Implications:
- Metronidazole-induced pancreatitis is a rare but significant adverse event.
- Further research is needed to understand the mechanism of metronidazole-induced pancreatitis.