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Related Experiment Videos

DCC expression is altered by multiple mechanisms in brain tumours

B C Ekstrand1, T A Mansfield, S H Bigner

  • 1Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.

Oncogene
|December 7, 1995
PubMed
Summary

The deleted in colorectal cancer (DCC) gene, crucial for brain tumor development, showed decreased or absent protein expression in over half of brain tumors studied. Its inactivation may play a significant role in brain tumor formation.

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Area of Science:

  • Oncology
  • Genetics
  • Neuroscience

Background:

  • The deleted in colorectal cancer (DCC) gene is a large candidate tumor suppressor gene located at chromosome 18q21.1.
  • DCC encodes a transmembrane protein with a currently unknown function.
  • DCC exhibits high expression levels in the brain compared to other adult tissues.

Purpose of the Study:

  • To investigate the potential role of DCC inactivation in the pathogenesis of brain tumors.
  • To determine if alterations in DCC expression are present in brain tumor samples.

Main Methods:

  • Analysis of DCC protein expression in a cohort of thirty brain tumors.
  • Investigation of potential mechanisms for altered DCC expression, including allelic loss, aberrant splicing, and allele-specific transcript loss.

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Main Results:

  • Over 50% of the studied brain tumors displayed decreased or absent DCC protein expression.
  • Specific mutations within the DCC gene were not identified in the analyzed tumors.
  • Altered DCC expression was attributed to various mechanisms such as allelic loss and aberrant splicing.

Conclusions:

  • DCC inactivation, through mechanisms other than direct mutation, appears to be a significant factor in brain tumor development.
  • The findings suggest DCC is a relevant tumor suppressor in the context of brain oncogenesis.