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Nabumetone-associated interstitial nephritis

E Blackwell1, K Loughlin, F Dumler

  • 1St. John Hospital and Medical Center, Detroit, Michigan, USA.

Pharmacotherapy
|September 1, 1995
PubMed
Summary
This summary is machine-generated.

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Nonsteroidal anti-inflammatory drug (NSAID) nephropathy can cause severe kidney damage, including nephrotic syndrome and acute kidney injury. Early recognition and management are crucial for patient outcomes.

Area of Science:

  • Nephrology
  • Pharmacology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
  • NSAID-induced nephropathy is a known but often underdiagnosed complication.

Observation:

  • An 84-year-old woman presented with edema and decreased urine output after 6 months of nabumetone use.
  • She exhibited significant edema, electrolyte abnormalities, and severe proteinuria (3061 mg/dl).
  • Laboratory findings revealed acute kidney injury with elevated creatinine (2.7 mg/dl) and BUN (70 mg/dl).

Findings:

  • Renal biopsy confirmed tubular damage consistent with NSAID-induced nephropathy.
  • Despite diuresis and hemodialysis, the patient developed persistent nephrotic syndrome (13 g protein/day).
  • The patient experienced infectious complications and ultimately died.

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Implications:

  • This case highlights the potential for severe renal toxicity from NSAIDs, even with short-term use.
  • NSAID-induced nephropathy can lead to irreversible kidney damage and nephrotic syndrome.
  • Clinicians should maintain a high index of suspicion for NSAID-induced nephropathy in patients with unexplained kidney injury.