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Computer simulation of tablet motion in coating drum
1Department of Quality Control, Taiho Pharmaceutical Co., Ltd, Tokushima, Japan.
Pharmaceutical Research
|September 1, 1995
Abstract
Purpose:
The purpose is to develop a new method of finding optimal conditions in tablet coating operations with the use of computer simulation.
Methods:
DEM(Discrete Element Method), which calculates trajectories of individual tablets by numerically integrating Newton's equations of motion, was used in this simulation.
Results:
The effects of tablet size, tablet loading, rotation speed on mean surface time, circulation time, and surface time deviation agree qualitatively with experimental results by other workers.
Conclusions:
It is found that DEM is a useful method of predicting tablet motion in a coating drum.