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Synthesis and biological activity of 1,2,4-triazinotriazinone derivatives
A M Abdel-Halim1, Z el-Gendy, R M Abdel-Rahman
1Department of Chemistry, Faculty of Education, Ain-Shams-University, Roxy, Cairo, Egypt.
Die Pharmazie
|November 1, 1995
Abstract:
The synthesis of 1,2,4-triazines bearing a 1,2,4-triazinone moiety and of 1,2,4-triazolo[4,3-b]-1,2,4-triazonones have been achieved by reaction of 1,6-dihydro-3-hydrazino-6-spiro- (9-fluorenyl)-1,2,4-triazin-5(4H)-one with various oxo- and halo-compounds. Structures of the products have been deduced by elemental analysis and spectral data. Significant anti-HIV and anticancer activities were observed in vitro for some members of the series.