Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Third generation time-resolved immunofluorometric TSH assay for automatic immunoassay system evaluated

E Taimela1, M Aalto, J Viikari

  • 1Department of Clinical Chemistry, Central Laboratory, University Central Hospital of Turku, Finland.

Scandinavian Journal of Clinical and Laboratory Investigation
|October 1, 1995
PubMed
Summary

A new third-generation thyrotropin (TSH) assay, AutoDelfia hTSH Ultra, demonstrates high sensitivity and precision. This automated immunoassay system offers improved performance for thyroid function testing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary Saturated Fat and Bone Health in Young Adults: The Young Finns Cohort.

Calcified tissue international·2022
Same author

Childhood Oral Infections Associate with Adulthood Metabolic Syndrome: A Longitudinal Cohort Study.

Journal of dental research·2020
Same author

Geographic origin as a determinant of left ventricular mass and diastolic function - the Cardiovascular Risk in Young Finns Study.

Scandinavian journal of public health·2018
Same author

Education as a moderator of genetic risk for higher body mass index: prospective cohort study from childhood to adulthood.

International journal of obesity (2005)·2017
Same author

Early work-related physical exposures and low back pain in midlife: the Cardiovascular Risk in Young Finns Study.

Occupational and environmental medicine·2016
Same author

Comprehensive real-time epidemiological data from respiratory infections in Finland between 2010 and 2014 obtained from an automated and multianalyte mariPOC® respiratory pathogen test.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2016

Area of Science:

  • Clinical Chemistry
  • Endocrinology
  • Immunoassay Technology

Background:

  • Thyrotropin (TSH) is a key hormone for assessing thyroid function.
  • Third-generation TSH assays have improved sensitivity for detecting subnormal TSH levels.
  • Automated immunoassay systems enhance laboratory efficiency and diagnostic capabilities.

Purpose of the Study:

  • To evaluate the performance of a new, third-generation serum TSH assay (AutoDelfia hTSH Ultra).
  • To assess the functional sensitivity, precision, and agreement with a previous TSH assay.
  • To determine the utility of the assay in various clinical scenarios.

Main Methods:

  • Evaluation of the AutoDelfia hTSH Ultra assay on the 1235 AutoDelfia system.
  • Determination of functional sensitivity and imprecision (within- and between-assay).

Related Experiment Videos

  • Comparison with a second-generation TSH-IRMA assay using patient serum samples.

    • Main Results:

    • Functional sensitivity was 0.007 mIU/L with 20% CV.
    • Between-assay CVs ranged from 4.1-7.7% across TSH concentrations of 0.026-23.8 mIU/L.
    • Good agreement was observed between the new assay and the TSH-IRMA (mean difference -0.04 mIU/L).

    Conclusions:

    • The AutoDelfia hTSH Ultra assay provides high sensitivity and precision for serum TSH measurement.
    • The automated system offers benefits in speed, convenience, and throughput.
    • This assay is suitable for evaluating thyroid function across diverse patient populations.