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[Mumps: efficacy of booster immunization]

M Gassner, U Hess, R Berger

    Schweizerische Medizinische Wochenschrift
    |December 26, 1995
    PubMed
    Summary

    A second mumps vaccination dose (booster) effectively increased antibody titers in most children previously vaccinated but with low immunity. This suggests a two-dose schedule is crucial for preventing mumps complications.

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    Area of Science:

    • Immunology
    • Vaccinology
    • Virology

    Context:

    • Assessing immune response in children with documented mumps vaccination but low antibody titers (< 3 PEI).
    • Investigating the efficacy of a booster dose of Triviraten Berna (Rubini mumps strain) in non-responsive children.
    • Evaluating antibody response at 7, 28, and 90 days post-booster.

    Purpose:

    • To determine if a booster vaccination can elicit a sustained immune response in children with inadequate prior immunity.
    • To compare the immune response to homologous (Rubini) versus heterologous (Jeryl Lynn, Urabe) mumps vaccine strains.
    • To ascertain the necessity of a two-dose immunization schedule for effective mumps prevention.

    Summary:

    • Ten children with low anti-mumps antibodies received a booster. Those boosted with the homologous Rubini strain showed a sustained antibody rise for 3 months.
    • Children primed with Jeryl Lynn showed a transient primary response, while the Urabe-primed child had no significant response.
    • Revaccination with homologous virus induced a persistent response, whereas heterologous virus elicited a response with limited antibody persistence.

    Impact:

    • Demonstrates the efficacy of a second mumps vaccine dose in 90% of children, highlighting its importance for robust immunity.
    • Suggests that a two-dose immunization schedule is essential for effectively preventing serious mumps complications.
    • Indicates that the choice of vaccine strain in primary and booster doses impacts the persistence of circulating antibodies.

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