Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Shear-augmented dispersion in the respiratory system

R D Kamm1

  • 1Department of Mechanical Engineering, Masschusetts Institute of Technology, Cambridge, USA.

Symposia of the Society for Experimental Biology
|January 1, 1995
PubMed
Summary

Shear-augmented dispersion enhances material dispersal in biological systems like the respiratory system. This review examines its role in bolus dispersion and high-frequency ventilation, offering insights into complex transport phenomena.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model.

Biomaterials·2018
Same author

PO-12 - The key role of talin-1 in cancer cell extravasation dissected through human vascularized 3D microfluidic model.

Thrombosis research·2016
Same author

Modeling the Blood-Brain Barrier in a 3D triple co-culture microfluidic system.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2016
Same author

Using microfluidics to investigate tumor cell extravasation and T-cell immunotherapies.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2016
Same author

In vitro models of the metastatic cascade: from local invasion to extravasation.

Drug discovery today·2013
Same author

Mechano-sensing and cell migration: a 3D model approach.

Physical biology·2011

Area of Science:

  • Fluid dynamics
  • Biomedical engineering
  • Transport phenomena

Background:

  • Biological systems exhibit shear-augmented dispersion, where velocity gradients enhance material dispersal.
  • This phenomenon is crucial in respiratory and cardiovascular systems, pollutant dispersal, and groundwater contamination.
  • Understanding these processes is vital for various scientific and engineering applications.

Purpose of the Study:

  • To review fundamental studies on shear-augmented dispersion.
  • To focus on its application in respiratory system examples: bolus dispersion and high-frequency ventilation.
  • To present a scaling analysis for effective diffusivities in complex scenarios.

Main Methods:

  • Review of fundamental studies on shear-augmented dispersion.
  • Analysis of specific respiratory system examples (bolus dispersion, high-frequency ventilation).
  • Inclusion of factors like turbulence, secondary flows, wall absorption, aerosol deposition, complex geometries, and oscillatory flow.
  • Development of a scaling analysis for effective diffusivities.

Main Results:

  • Shear-augmented dispersion significantly enhances material transport in biological and environmental flows.
  • The review highlights key features influencing dispersion, including turbulence and complex geometries.
  • A scaling analysis provides approximate dependencies for effective diffusivities.

Conclusions:

  • Shear-augmented dispersion is a critical mechanism for enhanced transport in diverse systems.
  • The study provides a framework for understanding and analyzing dispersion in complex biological and environmental contexts.
  • The scaling analysis offers a practical tool for estimating effective diffusivities when detailed models are intractable.

Related Experiment Videos