Relating isobolograms to response surfaces
Related Experiment Video
Updated: Aug 9, 2026

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
Published on: January 31, 2014
1Department of Biostatistics, Virginia Commonwealth University, Richmond 23298-0032, USA.
Abstract:
The interaction index, isobologram and the appropriate contour of constant response of a dose response surface each offer essentially equivalent information regarding departures from additivity in a chemical combination. The benefit of relating the interaction index and isobolograms to a contour of a fitted dose response surface is that departures from additivity can be related to parameters of a statistical model. This permits an assessment of the statistical significance of the parameters and conclusions regarding the nature of departures from additivity which account for the variability inherent in the experiments used to generate the data. Relationships between statistical models and experimental designs can be exploited to yield economical designs for studying chemical combinations.
More Related Videos
06:00Optimization of the Epimedii Folium Mutton-Oil Processing Technology and Testing Its Effect on Zebrafish Embryonic Development
Published on: March 17, 2023
09:16Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
Published on: May 12, 2023
Related Concept Videos
Free-body Diagrams: Problem Solving
For example, consider a block with a mass of 10 kg released on an inclined plane at an angle of 30° to the horizontal, where the...
Shear and Bending Moment Diagram: Problem Solving
Draw a Free-Body Diagram: Start by drawing a free-body diagram of the entire beam, including the concentrated loads, distributed load, and reaction...
Bode Plots Construction
Relation between Mathematical Equations and Block Diagrams
Response Surface Methodology
The process of RSM involves several key steps:
Methods of Medium Optimization