Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Risk-based concentrations: prioritizing environmental problems using limited data

R L Smith1

  • 1U.S. Environmental Protection Agency, Philadelphia, PA 19107, USA.

Toxicology
|January 8, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The tetratricopeptide repeats of Ssn6 interact with the homeo domain of alpha 2.

Genes & development·1995
Same author

Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor.

The Journal of pharmacology and experimental therapeutics·1995
Same author

Measured context-sensitive half-times of remifentanil and alfentanil.

Anesthesiology·1995
Same author

Gelatin fragments block adherence of Candida albicans to extracellular matrix proteins.

Microbiology (Reading, England)·1995
Same author

Central venous catheter infection rates in an acute care hospital.

Journal of intravenous nursing : the official publication of the Intravenous Nurses Society·1995
Same author

Cloning of the mgtE Mg2+ transporter from Providencia stuartii and the distribution of mgtE in gram-negative and gram-positive bacteria.

Journal of bacteriology·1995
Same journal

Retraction notice to "Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro" [Toxicology 283 (2011) 129-139].

Toxicology·2026
Same journal

Crystalline silica particles exposure modulated miRNA expression profiles in human macrophage-like THP-1 cells.

Toxicology·2026
Same journal

Sex-Specific Cellular and Molecular Mechanisms of PFAS-Induced Reproductive Toxicity.

Toxicology·2026
Same journal

Neurotoxicity and Mechanisms of Deltamethrin and Its Metabolite 3-PBA in HT22 Cells.

Toxicology·2026
Same journal

Polystyrene nanoplastics impair epithelial barrier establishment and modulate extracellular vesicle release in human bronchial cells cultured at the air-liquid interface.

Toxicology·2026
Same journal

Effects of HFPO-DA (GenX) exposure on placental glycolysis and metabolic microenvironment in pregnant rats.

Toxicology·2026
See all related articles

Regulatory agencies can prioritize environmental risks using a quantitative health risk assessment approach. This method combines toxicological data with exposure assumptions to create risk-based concentrations for contaminants, aiding in problem prioritization.

Area of Science:

  • Environmental Health Risk Assessment
  • Toxicology
  • Environmental Science

Background:

  • Regulatory agencies face challenges prioritizing environmental issues with limited data.
  • Existing United States Environmental Protection Agency (USEPA) methods provide toxicological constants for many substances.
  • Effective prioritization requires integrating toxicological data with exposure scenarios.

Purpose of the Study:

  • To develop a quantitative approach for prioritizing environmental problems based on potential health risks.
  • To incorporate USEPA risk assessment methods into a practical prioritization framework.
  • To create risk-based concentrations for numerous contaminants across various media.

Main Methods:

  • Utilized USEPA reference dose and slope factor values.

Related Experiment Videos

  • Combined toxicological constants with predetermined risk levels (10(-6) cancer risk or reference dose).
  • Incorporated protective human exposure assumptions (e.g., body mass, exposure duration, ingestion rates).

    • Main Results:

    • Generated risk-based concentrations for 596 contaminants in air, drinking water, fish, and soil.
    • Developed a method for regulatory officials to calculate ratios between environmental levels and risk-based concentrations.
    • These ratios serve as a surrogate for potential health impacts, enabling prioritization.

    Conclusions:

    • The developed risk-based concentrations are likely protective of human health due to USEPA's conservative estimation methods.
    • The quantitative approach and calculated ratios provide a valuable tool for regulatory agencies to prioritize environmental health risks.
    • Automation of ratio calculation and ranking can enhance efficiency when searching environmental databases.