[Vitamine A acid therapy in autosomal dominantichtyosis (author's transl)]

In autosomal dominant ichthyosis, a permanent cure is impossible, and symptomatic treatment is most important. At present, known therapeutic procedures have had little or no influence in this disease. Following the application of 0.1% vitamin A acid ointment, especially in children, the skin became free of scales within a few weeks. After improvement, a maintenance dosage of one application per week in most cases was sufficient to avoid any recurrence. Possible side effects of this treatment are mentioned. Sereral possibilities regarding the mode of action of vitamin A acid are discussed.