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[A relationship between the breakpoint of the bcr gene and some hematologic parameters in patients with chronic
I Seferyńska1, E Brojer, M Sankowska
1Pracowni Biologii Molekularnej Zakładu Serologii Instytutu Hematologii i Transfuzjologii w Warszawie.
Acta Haematologica Polonica
|January 1, 1995
Abstract:
We examined the hybrid bcr/abl mRNA present in 59 patients with chronic myeloid leukemia, using the reverse transcription method and polymerase chain reaction. Bcr/abl gene was found in 98% of patients. 60% of patients had b3a2 type of translocation, 40% type b2a2. Patients with b3a2 type had higher platelet count at diagnosis presentation than patients with b2a2. Other hematological data were similar in both groups.