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Related Experiment Videos

[Trabecular meshwork and elastin]

K Segawa1

  • 1Department of Ophthalmology, Shinshu University School of Medicine, Nagano-ken, Japan.

Nippon Ganka Gakkai Zasshi
|December 1, 1995
PubMed
Summary
This summary is machine-generated.

Elastic fibers containing elastin in the trabecular meshwork are crucial for aqueous humor outflow resistance. Elastase treatment can reduce this resistance, offering a potential therapeutic strategy for glaucoma.

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Area of Science:

  • Ophthalmology
  • Biochemistry
  • Cell Biology

Context:

  • Elastic fibers, composed of microfibrils and elastin, are present in the trabecular meshwork (TM).
  • These fibers play a significant role in regulating aqueous humor outflow resistance.
  • Elastin is found in specific patterns in various glaucoma types, including primary open angle glaucoma, pseudoexfoliation glaucoma, and steroid glaucoma.

Purpose:

  • To investigate the role of elastic fibers and elastin in the trabecular meshwork.
  • To explore the impact of elastase on TM structure and aqueous humor outflow.
  • To examine the distribution of elastin and fibronectin in different glaucoma subtypes.

Summary:

  • Digesting TM tissues with elastase separates cells and reduces elastin, while perfusion with elastase lowers intraocular pressure by decreasing outflow resistance.

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  • Elastin is abundant in POAG, PE, and steroid glaucoma, whereas fibronectin is present in congenital and juvenile glaucoma.
  • TM tissues synthesize and secrete elastic fiber components in response to steroid hormones, and the elastin gene is expressed in human TM.

    • Impact:

    • Elastase treatment demonstrates a potential therapeutic approach for reducing intraocular pressure and outflow resistance in glaucoma.
    • Understanding elastin's role in TM is key to developing novel glaucoma treatments.
    • Orally administered elastase can reach the aqueous humor and digest TM elastin, suggesting a viable drug delivery method.