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Ultrastructure of the microvasculature in human endometrial hyperplasia
D V Horbelt1, D K Roberts, T H Parmley
1Department of Obstetrics and Gynecology, University of Kansas School of Medicine-Wichita, Wesley Medical Center 67214-4976, USA.
Objective:
Our purpose was to determine the effect of hyperplasia on cell-to-cell communication in the microvasculature of the human endometrium.
Study Design:
Ten biopsy specimens of simple and complex hyperplasia of the human endometrium were investigated by electron microscopy.
Results:
The microvasculature of the hyperplastic endometrium shows morphologic disorder. The extracellular matrix is altered, and cell death is widespread. Intercellular contact is infrequent or absent.
Conclusions:
These results are in marked contrast to the ultrastructure of the normal microvasculature. The complex cell-to-cell interaction observed in normal tissue appears lost. This report, combined with others, indicates that cell-to-cell contact is sparse in hyperplastic endometrium.