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[Severe acute buflomedil poisoning]

V Piriou1, D Jacques, C Guérin

  • 1Service de Réanimation Médicale, Centre Hospitalier Lyon-Sud, Pierre-Bénite.

Annales Francaises D'Anesthesie Et De Reanimation
|January 1, 1995
PubMed
Summary

Buflomedil intoxication can be severe, leading to seizures and cardiac arrest. Early cardiac complications are the primary concern in buflomedil poisoning, requiring supportive care.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Emergency Medicine

Background:

  • Buflomedil is a vasodilator with papaverinic and alpha-adrenolytic properties.
  • The potential severity of buflomedil acute intoxication is often underestimated.
  • This case highlights the critical risks associated with high-dose buflomedil ingestion.

Observation:

  • An 18-year-old female ingested a large quantity of buflomedil.
  • She presented with seizures, ventricular arrhythmias, circulatory arrest, and deep coma (GCS=3).
  • Elevated buflomedil blood concentration (97.3 mg/L) confirmed severe toxicity.

Findings:

  • The patient experienced severe cardiac complications, including ventricular arrhythmias and circulatory arrest.
  • Despite initial critical condition, hemodynamic status improved within 24 hours.

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  • Full recovery was achieved, with discharge on the eighth day.

    • Implications:

    • Buflomedil poisoning can lead to life-threatening cardiac events.
    • Prompt recognition and supportive management are crucial for patient survival.
    • This case underscores the need for increased awareness regarding buflomedil toxicity.