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Related Experiment Videos

LSD and d-amphetamine effects on fixed interval responding in the rat

C Ksir, S Nelson

    Pharmacology, Biochemistry, and Behavior
    |March 1, 1977
    PubMed
    Summary

    Lysergic acid diethylamide (LSD) decreased response rates in rats without significantly altering their behavior patterns. D-amphetamine, however, disrupted fixed-interval responding patterns without changing overall rates.

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    Area of Science:

    • Behavioral Neuroscience
    • Psychopharmacology
    • Animal Models

    Background:

    • Fixed-interval (FI) schedules of reinforcement are crucial for understanding temporal control of behavior.
    • Investigating the effects of psychoactive substances on operant conditioning provides insights into their neurobiological mechanisms.

    Purpose of the Study:

    • To compare the effects of lysergic acid diethylamide (LSD) and d-amphetamine on fixed-interval (FI) and fixed-ratio (FR) schedules of reinforcement in rats.
    • To determine how these drugs impact response rates and response patterns under different schedules.

    Main Methods:

    • Rats were trained on an FI 3-min schedule, followed by a multiple FI/FR schedule.
    • Graded doses of LSD and d-amphetamine were administered before daily sessions.
    • Behavioral data, including response rates and patterns, were analyzed.

    Main Results:

    • LSD decreased overall response rates at higher doses (≥0.32 mg/kg) but largely preserved the FI pattern.
    • D-amphetamine did not significantly alter overall response rates but dose-dependently disrupted the FI pattern.
    • These effects were consistent across both FI and multiple FI/FR schedules.

    Conclusions:

    • LSD primarily affects response output quantity rather than the temporal patterning of behavior under these schedules.
    • D-amphetamine modulates the temporal organization of behavior, selectively enhancing low rates and potentially decreasing high rates within an interval.
    • The distinct effects of LSD and d-amphetamine highlight differential mechanisms of action on operant behavior regulation.

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