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Tetracyclines and calcified tissues
P van der Bijl1, G Pitigoi-Aron
1Department of Oral Medicine and Periodontics, Faculty of Dentistry, University of Stellenbosch, Tygerberg, South Africa.
Annals of Dentistry
|January 1, 1995
Summary
Tetracyclines, used in medicine and dentistry, bind to calcium and can stain teeth and bones. This review covers tetracycline pharmacology, tissue incorporation, and managing stained teeth.
Area of Science:
- Pharmacology
- Biochemistry
- Dental Medicine
Background:
- Tetracyclines are frequently prescribed for various medical and dental conditions.
- These antibiotics possess the ability to chelate calcium ions.
- This property leads to their incorporation into developing bones and teeth during the calcification process.
Purpose of the Study:
- To review the existing literature on tetracycline pharmacology.
- To examine the mechanisms of tetracycline incorporation into calcified tissues.
- To discuss current management strategies for tetracycline-induced tooth discoloration.
Main Methods:
- Literature review of pharmacological studies.
- Analysis of research on drug incorporation into bone and dental tissues.
- Synthesis of information on clinical management of stained teeth.
Main Results:
- Tetracyclines bind to calcium, leading to deposition in mineralizing tissues.
- The extent of incorporation depends on the timing of drug administration during calcification.
- Various treatment modalities exist for managing tetracycline-stained teeth.
Conclusions:
- Understanding tetracycline pharmacology is crucial for predicting and managing side effects.
- The incorporation into teeth and bones is a significant characteristic of this drug class.
- Effective management options are available for patients with tetracycline-stained teeth, improving aesthetic outcomes.