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Granisetron-dexamethasone combination for multiple day cisplatin
P Pronzato1, P L Losardo, F Vaira
1Department of Medical Oncology, Ospedale S. Andrea, La Spezia, Italy.
Anticancer Research
|September 1, 1995
Summary
This study found that combining granisetron and dexamethasone effectively controls nausea and vomiting in patients receiving multi-day cisplatin chemotherapy. The antiemetic treatment showed mild toxicity and high efficacy in managing chemotherapy-induced side effects.
Area of Science:
- Oncology
- Pharmacology
Background:
- Cisplatin is a widely used chemotherapy agent associated with significant nausea and vomiting.
- Effective antiemetic control is crucial for patient tolerance and adherence to polychemotherapy schedules.
Purpose of the Study:
- To evaluate the efficacy and tolerability of a granisetron and dexamethasone combination regimen.
- To assess antiemetic control in patients undergoing multi-day cisplatin chemotherapy.
Main Methods:
- A prospective study involving 34 patients receiving polychemotherapy with cisplatin (20 mg/sm for 5 days).
- Patients received intravenous granisetron (3 mg) and dexamethasone (8 mg) prior to cisplatin administration.
- Response was categorized as complete (no vomiting) or major (<= 2 vomiting episodes).
Main Results:
- A complete response was observed in 14 patients (41%).
- A major response was achieved in 12 patients (35%).
- The antiemetic regimen demonstrated mild toxicity.
Conclusions:
- The combination of granisetron and dexamethasone provides high antiemetic control in patients receiving multi-day cisplatin chemotherapy.
- This regimen is a viable option for managing chemotherapy-induced nausea and vomiting in this patient population.