Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Considerations and problems in the development of the mini-spindle pump

J Hager1, J Koller, F Gschnitzer

  • 1Surgical Clinic I, University of Innsbruck, Austria.

Artificial Organs
|July 1, 1995
PubMed
Summary

This study developed an implantable mini-spindle pump for assisted circulation. Early prototypes showed promise but caused significant blood trauma (hemolysis), necessitating design modifications to improve biocompatibility.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

Acellular Dermal Matrix in Plastic and Reconstructive Surgery.

Physiological research·2023
Same author

Fish early life stage toxicity prediction from acute daphnid toxicity and quantum chemistry.

SAR and QSAR in environmental research·2021
Same author

Preparation and processing of human allogenic dermal matrix for utilization in reconstructive surgical procedures.

Bratislavske lekarske listy·2020
Same author

Adipose derived mesenchymal stem cells harvesting.

Bratislavske lekarske listy·2019
Same author

Toxic epidermal necrolysis data from the CELESTE multinational registry. Part II: Specific systemic and local risk factors for the development of infectious complications.

Burns : journal of the International Society for Burn Injuries·2018

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Hemodynamics

Background:

  • Development of implantable devices for assisted circulation is crucial for treating heart failure.
  • Existing devices face challenges with efficiency and blood compatibility.

Purpose of the Study:

  • To design and evaluate a novel mini-spindle pump for assisted circulation.
  • To assess and minimize blood trauma (hemolysis) during device operation.

Main Methods:

  • Initial prototype design based on hydrodynamic calculations for water circulation.
  • Testing in mock circulation and subsequent evaluation in a Maxima oxygenator with blood.
  • Iterative design modifications of the rotor and housing to reduce hemolysis.

Main Results:

Related Experiment Videos

  • First prototype achieved high flow rates in mock circulation but caused significant hemolysis (>250 mg% free hemoglobin).
  • Modified prototypes showed improved flow (4.3-4.5 L/min) and reduced hemolysis (down to 180 mg% in one iteration), but blood trauma remained a concern.
  • Fourth prototype improved function but increased blood trauma compared to the third.

Conclusions:

  • The mini-spindle pump design requires further optimization to balance flow efficiency and hemocompatibility.
  • Reducing blood trauma is a critical challenge for the successful clinical application of this assisted circulation device.