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Related Experiment Videos

Normal respiratory chain function in patients with low-tension glaucoma

E J Brierley1, P G Griffiths, K Weber

  • 1Division of Clinical Neuroscience, University of Newcastle upon Tyne, England.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|February 1, 1996
PubMed
Summary

This study investigated if low-tension glaucoma stems from mitochondrial defects, similar to Leber's hereditary optic neuropathy. Researchers found no evidence of systemic mitochondrial respiratory chain defects in glaucoma patients.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Mitochondrial Biology

Background:

  • Low-tension glaucoma (LTG) is an optic neuropathy with unclear pathogenesis.
  • Leber's hereditary optic neuropathy (LHON) is a maternally inherited optic neuropathy linked to mitochondrial DNA mutations.
  • A potential link between LTG and mitochondrial dysfunction has been proposed.

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