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Related Experiment Videos

Acute dermatomyositis-polymyositis and malignancy

J H Talbott

    Seminars in Arthritis and Rheumatism
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Dermatomyositis with malignancy (AD-P) is a rare condition where cancer is linked to muscle weakness and skin issues. This review enhances understanding with new cases, highlighting consistent clinical findings across various tumors.

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    Area of Science:

    • Neurology
    • Oncology
    • Dermatology

    Background:

    • Dermatomyositis with malignancy (AD-P) is a rare paraneoplastic syndrome.
    • The association between AD-P and malignancy has been documented since 1916.
    • Clinical presentation of AD-P with malignancy is consistent across various tumor types.

    Purpose of the Study:

    • To review and present data on AD-P associated with malignancy.
    • To highlight the consistent clinical findings in AD-P with malignancy.
    • To discuss the potential for future differentiation between AD-P, polymyositis, and other malignancy-associated syndromes.

    Main Methods:

    • Review of published case reports of AD-P associated with malignancy.
    • Inclusion of 15 unreported cases of AD-P with malignancy.

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  • Analysis of clinical data, including muscle weakness, skin lesions, and tumor type.

    • Main Results:

    • The association of AD-P with malignancy has a long history, with numerous cases reported.
    • Clinical findings in AD-P with malignancy, such as proximal muscle weakness and skin lesions, are remarkably consistent.
    • A minority of AD-P patients with malignancy may lack prominent skin lesions, emphasizing the need for careful monitoring.

    Conclusions:

    • AD-P associated with malignancy presents with consistent clinical features, primarily proximal muscle weakness and skin manifestations.
    • Distinguishing AD-P from polymyositis and other malignancy-associated syndromes may require future identification of specific immunologic markers.
    • Management challenges in AD-P and polymyositis are similar, particularly when associated with malignancy.