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Erythrocyte complement receptors

D J Birmingham1

  • 1Department of Internal Medicine, Ohio State University, Columbus, USA.

Critical Reviews in Immunology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Primate erythrocytes have complement receptors (E-CR) that bind immune complexes, aiding their clearance. Reduced E-CR levels in diseases like lupus may worsen the condition.

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Phenotypes, genotypes and disease susceptibility associated with gene copy number variations: complement C4 CNVs in European American healthy subjects and those with systemic lupus erythematosus.

Cytogenetic and genome research·2009

Area of Science:

  • Immunology
  • Hematology

Background:

  • Primate erythrocytes express complement receptors (E-CR) that bind C3b and C4b.
  • This binding facilitates immune adherence and inhibits complement activation.

Purpose of the Study:

  • To investigate the structure and function of erythrocyte complement receptors (E-CR) in primates.
  • To understand the role of E-CR in immune complex clearance and its implications in diseases like SLE.

Main Methods:

  • Comparative analysis of E-CR in human and non-human primates.
  • Examination of E-CR function in immune adherence and complement regulation.

Main Results:

  • Human E-CR is complement receptor type 1 (CR1), with polymorphic allotypes.
  • Non-human primate E-CR are smaller than human CR1 but functionally and antigenically similar.

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  • Reduced erythrocyte CR1 levels are observed in systemic lupus erythematosus (SLE) patients, correlating with disease activity.

    • Conclusions:

    • Erythrocyte CR1 functions as a shuttle for immune complexes (IC) to the monocyte phagocytic system.
    • Loss of erythrocyte CR1 may be a pathogenic factor in the development and severity of SLE.