Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD28 and apoptosis

L H Boise1, P J Noel, C B Thompson

  • 1Howard Hughes Medical Institute, University of Chicago, IL 60637-5420, USA.

Current Opinion in Immunology
|October 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial Depolarization During TNF-induced Apoptosis is Caspase-dependent and Independent of Bcl-x L and the Permeability Transition Pore.

TheScientificWorldJournal·2018
Same author

14-3-3ζ binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors.

Leukemia·2017
Same author

Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion.

Nature communications·2017
Same author

Molecular impact of selective NFKB1 and NFKB2 signaling on DLBCL phenotype.

Oncogene·2017
Same author

Enhancing Brain Lesions during Acute Optic Neuritis and/or Longitudinally Extensive Transverse Myelitis May Portend a Higher Relapse Rate in Neuromyelitis Optica Spectrum Disorders.

AJNR. American journal of neuroradiology·2017
Same author

Dexamethasone treatment promotes Bcl-2 dependence in multiple myeloma resulting in sensitivity to venetoclax.

Leukemia·2015
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

Signal transduction via CD28 and CTLA4 molecules plays a crucial role in T-cell activation and survival. This signaling pathway influences T-cell proliferation, subset selection, and prevents graft rejection by regulating cell death.

Area of Science:

  • Immunology
  • Cellular Biology
  • Molecular Signaling

Background:

  • T-cell activation and anergy are regulated by signal transduction pathways involving CD28 and CTLA4.
  • Soluble CTLA4 has been implicated in preventing graft rejection by binding B7-1 and B7-2 ligands.
  • The role of CD28 costimulation in T-cell survival was recently investigated.

Purpose of the Study:

  • To investigate the role of CD28 costimulation in regulating T-cell survival.
  • To explore the contrasting effects of CD28 and CTLA4 signaling on T-cell fate.
  • To understand how B7-1/B7-2 signaling impacts T-cell proliferation, subset selection, and survival.

Main Methods:

  • Analysis of signal transduction pathways involving CD28 and CTLA4.
  • Investigating the effects of CD28 costimulation on IL-2 production and Bcl-xL expression.

Related Experiment Videos

  • Examining CTLA4-mediated signal transduction in previously activated T cells.

    • Main Results:

    • CD28 costimulation enhances IL-2 production and augments Bcl-xL expression, promoting T-cell survival.
    • CTLA4-mediated signal transduction has been reported to induce cell death in activated T cells.
    • B7-1/B7-2 signaling influences T-cell proliferation, T-helper cell subset selection, and T-cell survival.

    Conclusions:

    • CD28 and CTLA4 signaling have distinct roles in regulating T-cell fate, impacting survival and proliferation.
    • B7-1/B7-2 interactions are critical regulators of T-cell responses beyond just proliferation and subset selection.
    • Understanding these pathways is crucial for controlling immune responses and preventing graft rejection.