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Cancer chemoprevention
1Department of Thoracic/Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Journal of the National Cancer Institute. Monographs
|January 1, 1995
Summary
Chemoprevention uses chemical agents to suppress cancer development by blocking mutagenesis and controlling cell growth. This promising strategy requires further development of effective, less toxic agents for widespread use.
Area of Science:
- Oncology
- Preventive Medicine
- Pharmacology
Background:
- Chemoprevention is an emerging strategy for cancer prevention and control.
- It involves using chemical agents to reverse or suppress carcinogenesis.
- This approach is supported by concepts like field cancerization and multistep carcinogenesis.
Purpose of the Study:
- To define chemoprevention and its underlying mechanisms.
- To highlight the potential of chemopreventive agents like retinoids and tamoxifen.
- To emphasize the ongoing need for developing improved chemopreventive therapies.
Main Methods:
- Review of existing literature on chemoprevention.
- Analysis of the mechanisms of action for chemopreventive agents.
- Evaluation of clinical trial data for efficacy and safety.
Main Results:
- Chemoprevention agents can block mutagenesis and regulate cellular processes in epithelial tissues.
- Clinical efficacy has been demonstrated by agents such as retinoids and tamoxifen.
- Promising results from trials indicate significant interest in chemoprevention.
Conclusions:
- Chemoprevention holds significant promise for cancer prevention and control.
- Further research is crucial for developing more effective and less toxic agents.
- Establishing chemoprevention as a standard therapy requires continued investigation and validation.